MOTIVATION




Needless chemotherapeutic therapy of cancer can be avoided if the chemosensitivity of the tumor is known prior to the therapy. Additional it is possible to avoid the development of a resistance of the cancer. Analysis of chemosensitivity can be achieved with animal experiments. But one aim - since many years - is to reduce the amount of animal experiments.
A solution is possible with biohybrid systems. Here a combination of microsensors and biological cells or tissue acts as the test organism. So an in vivo surrounding can be simulated and the reactions toward addition of chemotherapeutica can be investigated.

Important factors are the cellular oxygen consumption and the extracelluar acidification of cancer cells. In the course of this research project a microelectronic sensor shall be optimized toward this two parameters.